Classical and Molecular Genetics

Course Code:

GBE212

Course Period:

Spring

Course Type:

Core

Credits:

3

Theoric:

2

Practice:

2

Laboratory Hour:

0

ECTS:

6

Prerequisite Courses:

Biology I

Course Language:

English

Course Coordinator:

Gamze Torun Köse

Courses given by:

Gamze Torun Köse

Course Objectives:

The major goals in this course are to ensure that the students gain basic genetics and molecular biology background at a theoretical level, that they have the capability to design and carry out experiments in genetics and bioengineering fields and thus to provide effective solutions to questions and problems that they may face in the future.

Course Content:

The course provides the concepts of cell division, Mendelian Genetics and its Extensions, Linkage and Gene Mapping in Eukaryotes, Sex Chromosomes, Chromosome Structures and Mutations, DNA Structure and Analysis, DNA Replication, Transcription, Translation, Gene Mutation, DNA Repair and Transposable Elements, Genetics of Bacteria, Regulation of Gene Expression in Prokaryotes and Eukaryotes, Recombinant DNA Technology.

Course Methodology:

1: Lecture by instructor, 2: Lecture by instructor with class discussion, 3: Problem solving by instructor, 4: Use of simulations, 5: Problem solving assignment, 6: Reading assignment, 7: Laboratory work, 8: Term research paper, 9: Presentation by guest s

Course Evaluation Methods:

A: Written exam, B: Multiple-choice exam C: Take-home quiz, D: Experiment report, E: Homework, F: Project, G: Presentation by student, H: …

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Course Learning Outcomes

Course Learning Outcomes	Detailed Program Outcomes	Teaching Methods	Assessment Methods
Ability to interpret Classical Genetics and analyse its problems	1, 3, 5	1, 3, 5	A, B, E
Ability to interpret Linkage and Gene Mapping in Eukaryotes	1, 3, 5	1, 3, 5	A, B, E
Ability to interpret Genetics of Bacteria	1, 3, 5	1, 3, 5	A, B
Ability to analyse chromosome structure and mutations	1	1	A, B
Ability to analyse DNA structure and define basics of Molecular Genetics and techniques	1	1	A, B
Ability to interpret DNA replication, transcription and translation	1	1	A, B
Ability to define gene mutation and DNA repair	1	1	A, B
Ability to interpret regulation of gene expression in both Prokaryotes and Eukaryotes	1	1	A, B
Ability to use Recombinant DNA technology	1	1	A, B

Course Flow

COURSE CONTENT
Week	Topics	Study Materials
1	Mitosis and Meiosis (11 Sept)	2
2	Mendelian Genetics (17 -18 Sept)	3
3	Extensions of Mendelian Genetics (24 -25 Sept)	4
4	Linkage, Crossing over and Mapping in Eukaryotes (1 -2 Oct)	5
5	Genetics of Bacteria (8 -9 Oct) Sex Chromosomes	6 7
6	Chromosome Mutations (15 -16 Oct)	8
7	DNA Structure and Analysis (22 -23 Oct) MIDTERM I (Lectures 1-6)	10
8	Chromosome Structure and DNA Sequence Organization (30 Oct)	12
9	DNA Replication and Recombination (5 -6 Nov) Transcription	11 13
10	Translation and Proteins (12 -13 Nov)	14
11	Gene Mutation, DNA Repair and Transposable Elements (19 -20 Nov)	15
12	Regulation of Gene Expression in Prokaryotes (26 -27 Nov)	16
13	MIDTERM II (Lectures 7-12) (3 -4 Dec) Regulation of Gene Expression in Eukaryotes	17
14	Recombinant DNA Technology (10 -11 Dec)	20

Recommended Sources

RECOMMENDED SOURCES

Textbook

Concepts of Genetics- W.S.Klug, M.R.Cummings, C.A.Spencer, M.A.Palladino

Additional Resources

Molecular biology of the gene-Watson, Baker, Bell, Gann, Levine,

Genetic Engineering- D.S.T. Nicholl

Genes VIII- B.Lewin

Material Sharing

MATERIAL SHARING
Documents	Handouts
Assignments	1 Homework
Exams	2 Midterm, 1 Final

Assessment

ASSESSMENT
IN-TERM STUDIES	NUMBER	PERCENTAGE
Midterm 1	1	30 %
Midterm 2	1	30 %
Total		60 %
CONTRIBUTION OF FINAL EXAMINATION TO OVERALL GRADE		40 %
CONTRIBUTION OF IN-TERM STUDIES TO OVERALL GRADE		±10 %
Total		100

Course’s Contribution to Program

COURSE'S CONTRIBUTION TO PROGRAM OUTCOMES
No	Program Learning Outcomes	check √
1a	Adequate knowledge in mathematics, science and engineering subjects pertaining to the relevant discipline,	√
1b	Ability to use theoretical and applied knowledge in these areas in complex engineering problems.
2a	Ability to identify, formulate, and solve complex engineering problems,	√
2b	Ability to select and apply proper analysis and modeling methods for this purpose.
3a	Ability to design a complex system, process, device or product under realistic constraints and conditions, in such a way as to meet the desired result,	√
3b	Ability to apply modern design methods for this purpose.
4a	Ability to devise, select and use modern techniques and tools needed for analyzing and solving complex problems encountered in engineering practice.	√
4b	Ability to employ information technologies effectively.
5a	Ability to design experiments for investigating complex engineering problems or discipline specific research questions,
5b	Ability to conduct experiments, gather data, analyze and interpret results for investigating complex engineering problems or discipline specific research questions.
6a	Ability to work efficiently in intra-disciplinary teams,
6b	Ability to work efficiently in multi-disciplinary teams,
6c	Ability to work individually.	√
7a	Ability to communicate effectively in Turkish, both orally and in writing,
7b	Knowledge of a minimum of one foreign language,
7c	Ability to write effective reports and comprehend written reports, prepare design and production reports,
7d	Ability to make effective presentations,
7e	Ability to give and receive clear and intelligible instructions.	√
8a	Recognition of the need for lifelong learning, ability to access information, ability to follow developments in science and technology,	√
8b	Ability to continue to educate him/herself.	√
9a	Consciousness to behave according to ethical principles and professional and ethical responsibility.	√
9b	Knowledge on standards used in engineering practice.	√
10a	Knowledge about business life practices such as project management, risk management, change management.
10b	Awareness in entrepreneurship and innovation.
10c	Knowledge about sustainable development.
11a	Knowledge about the global and social effects of engineering practices on health, environment, and safety,	√
11b	Knowledge about contemporary issues of the century reflected into the field of engineering.
11c	Awareness of the legal consequences of engineering solutions.

ECTS

ECTS ALLOCATED BASED ON STUDENT WORKLOAD BY THE COURSE DESCRIPTION
Activities	Quantity	Duration (Hour)	Total Workload (Hour)
Course Duration	14	4	56
Hours for off-the-classroom study (Pre-study, practice)	14	4	56
Mid-term examination	2	4	8
Homework	1	5	10
Final examination	1	4	4
Total Work Load			134
Total Work Load / 25 (h)			5,36
ECTS Credit of the Course			6

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Classical and Molecular Genetics

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