Cell Biology

Course Code:

GBE205

Course Period:

Autumn

Course Type:

Core

Credits:

4

Theoric:

2

Practice:

1

Laboratory Hour:

3

ECTS:

6

Course Language:

English

Course Coordinator:

Bahar Sogutmaz Ozdemir

Courses given by:

Bahar Sogutmaz Ozdemir

Course Objectives:

• To ensure that the students gain basic genetics and molecular biology background at a theoretical as well as practical level. • To teach students the concept of modern cell biology and chemistry of the cell including macromolecules. • To ensure that the students learn about the structure and function of cells and organelles. • To teach students the processes of replication, transcription, translation and gene regulation. • To teach students the membrane transport as well as intracellular transport. • To ensure that students learn the structures and functions of the cytoskeletal elements. • To teach students the basic concepts in cancer and cell signaling.

Course Content:

Evolution of the cell; discovering the cell structure and importance of cellular organization; cellular organelles; structure and function of cellular membranes; intracellular membrane networks; DNA packaging; the processes of replication, transcription, translation and gene regulation; cytoskeletal structure of the cell; extracellular structure and cell matrix; intercellular recognition and cell adhesion; the cell cycle and cell division; chemical signaling between cells; cellular differentiation; basic concepts in cancer.

Course Methodology:

1: Lecture by instructor, 2: Lecture by instructor with class discussion, 3: Problem solving by instructor, 4: Use of simulations, 5: Problem solving assignment, 6: Reading assignment, 7: Laboratory work, 8: Term research paper, 9: Presentation by guest s

Course Evaluation Methods:

A: Written exam, B: Multiple-choice exam C: Take-home quiz, D: Experiment report, E: Homework, F: Project, G: Presentation by student, H: …

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Course Learning Outcomes

Course Learning Outcomes	Detailed Program Outcomes	Teaching Methods	Assessment Methods
The ability to describe the structure and function of organelles found in prokaryotic and eukaryotic cells and the differences between these cells including cell membrane structure and function	1a, 1b, 4a, 6c, 7a, 7b, 8a, 8b	1, 2, 7	A, D
The ability to explain the processes; replication, transcription, translation and gene regulation	1a, 1b, 4a, 6c, 7a, 7b, 8a, 8b	1, 2, 7	A, D
The ability to define the basic components of the cytoskeleton types their structure and function	1a, 6c, 7a, 7b, 8a, 8b	1, 2, 7	A, D
The ability to explain the mechanisms in protein sorting and vesicular transport	1a, 1b, 6c, 7a, 7b, 8a, 8b	1, 2, 7	A, D
The ability to define basic concepts in cell signaling and cancer	1a, 1b, 6c, 7a, 7b, 8a, 8b	1, 2, 7	A, D
The ability to understand and apply experimental procedures, conduct experiments and report the results	1a, 1b, 2b, 4a, 5a, 5b, 6a, 6c, 7a, 7b, 7c, 8a, 8b, 9a	1, 2, 7	A, D

Course Flow

COURSE CONTENT
Week	Topics	Study Materials
1	Preview of the cell	Text Book, Slides and Laboratory Manual
2	Chemistry of the cell	Text Book, Slides and Laboratory Manual
3	The macromolecules of the cell	Text Book, Slides and Laboratory Manual
4	Cells and organelles Lab Session 1: Lab Safety Rules / How to Write a Lab Report	Text Book, Slides and Laboratory Manual
5	Genome (DNA & chromosomes) Lab Session 2: Microscopy	Text Book, Slides and Laboratory Manual
6	Midterm exam I Lab Session 3: Cell Counting	Text Book, Slides and Laboratory Manual
7	DNA replication Lab Session 4: Cell Motility	Text Book, Slides and Laboratory Manual
8	DNA to protein (Transcription and Translation) Lab Session 5: Cell Fractionation	Text Book, Slides and Laboratory Manual
9	Control of gene expression Lab Session 6: Protein Determination	Text Book, Slides and Laboratory Manual
10	Membrane structure, function and transport Lab Session 7: Immunocytochemistry	Text Book, Slides and Laboratory Manual
11	Midterm exam II Lab Session 8: PCR	Text Book, Slides and Laboratory Manual
12	Intracellular compartments and transport Lab Session 9: Gel Electrophoresis	Text Book, Slides and Laboratory Manual
13	Cytoskeleton Lab Final Exam	Text Book, Slides and Laboratory Manual
14	Cell signaling / Cancer	Text Book, Slides and Laboratory Manual

Recommended Sources

RECOMMENDED SOURCES

Textbook

Essential Cell Biology,Alberts&Bray&Hopkin&Johnson&Lewis&Raff&Roberts&Walter

Second Edition, Garland Science

World of the Cell, The International Edition 7.th Edition

Wayne Becker, Lewis Kleinsmith, Jeff Hardin, Gregory Bertoni

Molecular Biology of the Cell,

Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter, 5th edition, Garland Science, Taylor and Francis Group.

Additional Resources

Lecture notes and slides

Material Sharing

MATERIAL SHARING
Documents	Lecture Notes can be downloaded from Moodle. Laboratory Manuals are supplied and students are expected to bring the laboratory manuals to the lab session.
Assignments	Laboratory Reports will be submitted to Turnitin for evaluation one week after the laboratory practicals.

Assessment

ASSESSMENT
IN-TERM STUDIES	NUMBER	PERCENTAGE
Midterm Exams	2	2x15=30
Laboratory	9	35

Total		65
CONTRIBUTION OF FINAL EXAMINATION TO OVERALL GRADE		35
CONTRIBUTION OF IN-TERM STUDIES TO OVERALL GRADE		65
Total		100

Course’s Contribution to Program

COURSE'S CONTRIBUTION TO PROGRAM OUTCOMES
No	Program Learning Outcomes	check √
1a	Adequate knowledge in mathematics, science and engineering subjects pertaining to the relevant discipline,	√
1b	Ability to use theoretical and applied knowledge in these areas in complex engineering problems.	√
2a	Ability to identify, formulate, and solve complex engineering problems,
2b	Ability to select and apply proper analysis and modeling methods for this purpose.	√
3a	Ability to design a complex system, process, device or product under realistic constraints and conditions, in such a way as to meet the desired result,
3b	Ability to apply modern design methods for this purpose.
4a	Ability to devise, select and use modern techniques and tools needed for analyzing and solving complex problems encountered in engineering practice.	√
4b	Ability to employ information technologies effectively.
5a	Ability to design experiments for investigating complex engineering problems or discipline specific research questions,	√
5b	Ability to conduct experiments, gather data, analyze and interpret results for investigating complex engineering problems or discipline specific research questions.	√
6a	Ability to work efficiently in intra-disciplinary teams,	√
6b	Ability to work efficiently in multi-disciplinary teams,
6c	Ability to work individually.	√
7a	Ability to communicate effectively in Turkish, both orally and in writing,	√
7b	Knowledge of a minimum of one foreign language,	√
7c	Ability to write effective reports and comprehend written reports, prepare design and production reports,	√
7d	Ability to make effective presentations,
7e	Ability to give and receive clear and intelligible instructions.
8a	Recognition of the need for lifelong learning, ability to access information, ability to follow developments in science and technology,	√
8b	Ability to continue to educate him/herself.	√
9a	Consciousness to behave according to ethical principles and professional and ethical responsibility.	√
9b	Knowledge on standards used in engineering practice.
10a	Knowledge about business life practices such as project management, risk management, change management.
10b	Awareness in entrepreneurship and innovation.
10c	Knowledge about sustainable development.
11a	Knowledge about the global and social effects of engineering practices on health, environment, and safety,
11b	Knowledge about contemporary issues of the century reflected into the field of engineering.
11c	Awareness of the legal consequences of engineering solutions.

ECTS

ECTS ALLOCATED BASED ON STUDENT WORKLOAD BY THE COURSE DESCRIPTION
Activities	Quantity	Duration (Hour)	Total Workload (Hour)
Course Duration	14	3	42
Hours for off-the-classroom study (Pre-study, practice)	12	7	84
Mid-term examination	2	2	4
Experiment	9	3	27
Final Examination	1	3	3
Total Work Load			160
Total Work Load / 25 (h)			6.4
ECTS Credit of the Course			6

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