Molecular Biology I

Course Code:

GBE403

Course Period:

Autumn

Course Type:

Core

Credits:

3

Theoric:

3

Practice:

0

Laboratory Hour:

0

ECTS:

6

Prerequisite Courses:

Techniques in Genetics Engineering I

Course Language:

English

Course Objectives:

To introduce the students to molecular mechanisms of cellular functions and physiology and their regulation.

Course Content:

Cell chemistry and biosynthesis, proteins, DNA-chromosome-genomes, DNA replication-repair-recombination, energy conversion-mitochondria and chloroplast, the cell cycle and apoptosis, cancer

Course Methodology:

1: Lecture by instructor, 2: Lecture by instructor with class discussion, 3: Problem solving by instructor, 4: Use of simulations, 5: Problem solving assignment, 6: Reading assignment, 7: Laboratory work, 8: Term research paper, 9: Presentation by guest s

Course Evaluation Methods:

A: Written exam, B: Multiple-choice exam C: Take-home quiz, D: Experiment report, E: Homework, F: Project, G: Presentation by student, H: …

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Course Learning Outcomes

Course Learning Outcomes	Detailed Program Outcomes	Teaching Methods	Assessment Methods
1. Ability to describe the subcellular structures and their functions	1a, 8a, 8b	1,2	A,E
2. Ability to define the molecular mechanisms inside the cell	1a, 8a, 8b	1,2	A,E
3. Ability to explain cancer and related misregulation/dysfunction of cellular mechanisms	1a, 8a, 8b	1,2	A,E

Course Flow

COURSE CONTENT
Week	Topics	Study Materials
1	Introduction; cell chemistry and biosynthesis	Textbook Ch.2
2	Proteins	Textbook Ch.3
3	DNA-chromosome-genomes	Textbook Ch.4
4	DNA replication-repair-recombination	Textbook Ch.5
5	How cells read the genome DNA-to-Protein	Textbook Ch.6
6	Control of gene expression	Textbook Ch.7
7	Manipulating proteins, DNA, and RNA	Textbook Ch.8
8	Visualizing cells	Textbook Ch.9
9	MIDTERM EXAMINATION	Textbook Ch.1-9
10	Membrane structure	Textbook Ch.10
11	Intracellular compartments and protein sorting	Textbook Ch.12
12	Intracellular vesicular traffic	Textbook Ch.13
13	Energy conversion: mitochondria	Textbook Ch.14
14	Energy conversion: chloroplast	Textbook Ch.14
15	Mechanisms of cell communication	Textbook Ch.15

Recommended Sources

RECOMMENDED SOURCES
Textbook	Molecular Biology of the Cell; Bruce Alberts, Garland Science 6th ed
Additional Resources	Recent Research and Review Articles

Material Sharing

MATERIAL SHARING
Documents	Lecture notes are available online (Moodle-Coadsys) for download as pdf.
Assignments	Articles are available online (Moodle-Coadsys) for download as pdf
Exams	1 midterm and 1 final.

Assessment

ASSESSMENT
IN-TERM STUDIES	NUMBER	PERCENTAGE
Mid-terms	1	25
Assignment/Homework	5	35
Final	1	40
Total		100
CONTRIBUTION OF FINAL EXAMINATION TO OVERALL GRADE		40
CONTRIBUTION OF IN-TERM STUDIES TO OVERALL GRADE		60
Total		100

Course’s Contribution to Program

COURSE'S CONTRIBUTION TO PROGRAM OUTCOMES
No	Program Learning Outcomes	check √
1a	Adequate knowledge in mathematics, science and engineering subjects pertaining to the relevant discipline.	√
1b	Ability to use theoretical and applied knowledge in these areas in complex engineering problems.
2a	Ability to identify, formulate, and solve complex engineering problems.
2b	Ability to select and apply proper analysis and modeling methods for this purpose.
3a	Ability to design a complex system, process, device or product under realistic constraints and conditions, in such a way as to meet the desired result.
3b	Ability to apply modern design methods for this purpose.
4a	Ability to devise, select and use modern techniques and tools needed for analyzing and solving complex problems encountered in engineering practice.
4b	Ability to employ information technologies effectively.
5a	Ability to design experiments for investigating complex engineering problems or discipline specific research questions.
5b	Ability to conduct experiments, gather data, analyze and interpret results for investigating complex engineering problems or discipline specific research questions.
6a	Ability to work efficiently in intra-disciplinary teams.
6b	Ability to work efficiently in multi-disciplinary teams.
6c	Ability to work individually.
7a	Ability to communicate effectively in Turkish, both orally and in writing.
7b	Knowledge of a minimum of one foreign language.
7c	Ability to write effective reports and comprehend written reports, prepare design and production reports.
7d	Ability to make effective presentations.
7e	Ability to give and receive clear and intelligible instructions.
8a	Recognition of the need for lifelong learning, ability to access information, ability to follow developments in science and technology.	√
8b	Ability to continue to educate him/herself.	√
9a	Consciousness to behave according to ethical principles and professional and ethical responsibility.
9b	Knowledge on standards used in engineering practice.
10a	Knowledge about business life practices such as project management, risk management, change management.
10b	Awareness in entrepreneurship and innovation.
10c	Knowledge about sustainable development.
11a	Knowledge about the global and social effects of engineering practices on health, environment, and safety.
11b	Knowledge about contemporary issues of the century reflected into the field of engineering.
11c	Awareness of the legal consequences of engineering solutions.

ECTS

ECTS ALLOCATED BASED ON STUDENT WORKLOAD BY THE COURSE DESCRIPTION
Activities	Quantity	Duration (Hour)	Total Workload (Hour)
Course duration	14	3	42
Hours for off-the-classroom study (Pre-study, practice)	14	6	84
Mid-term examination	1	2	2
Homework	5	2	10
Final	1	3	3
Total Work Load			141
Total Work Load / 25 (h)			5.64
ECTS Credit of the Course			6

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Molecular Biology I

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